The Unseen Architects How Your Microbiome Affects the Immune Response and Skin Health

Main Article Content

Julia Quirós Jara
Daniela Hernández Gamboa

Abstract

This review explores the relationship between gut microbiome alterations and two immune-mediated conditions: systemic lupus erythematosus, an autoimmune disease, and atopic dermatitis, an immunodermatological disorder. The objective is to analyze how shifts in intestinal microbial composition contribute to the pathogenesis and clinical manifestations of these diseases. By synthesizing current evidence, this article highlights the potential of microbiome-targeted interventions as emerging strategies for prevention and treatment.

Downloads

Download data is not yet available.

Article Details

How to Cite
Quirós JaraJ., & Hernández GamboaD. (2025). The Unseen Architects. Acta Académica, 77(Nov), 141-160. Retrieved from http://201.196.25.14/index.php/actas/article/view/1409
Section
Acta Estudiantil

References

Abrahamsson, T., Jakobsson, H. E., Andersson, A., Björkstén, B., Engstrand, L., & Jenmalm, M. (2012). Low diversity of the gut microbiota in infants with atopic eczema. The Journal of Allergy and Clinical Immunology, 129(2), 434–440.e4402. https://doi.org/10.1016/j.jaci.2011.10.025
Campos, M. (2023). Leaky gut: What is it, and what does it mean to you? Harvard Health Publishing. https://www-health-harvard-edu.translate.goog/blog/leaky-gut-what-is-it-and-what-does-it-mean-for-you-2017092212451?_x_tr_sl=en&_x_tr_tl=es&_x_tr_hl=es&_x_tr_pto=tc
Cheeley, J., y Lawley, L.(2025). Eccema, psoriasis, infecciones de la piel, acné y otras enfermedades cutáneas comunes. En D. Longo, A. Fauci, D. Kasper, S. Hauser, J. Jameson, J. Loscalzo, S. Holland, & C. Langford (Eds.), Harrison. Principios de Medicina Interna (22.ª ed.). McGraw Hill. https://accessmedicina.mhmedical.com/content.aspx?bookid=3553§ionid=293455607
Habiballah, D., Li, F., & Jiang, L. (2025). Immune metabolic restoration in systemic lupus erythematosus: The impact of gut microbiota, probiotics, and nutritional synergy. Frontiers in Immunology, 16, 1602235. https://doi.org/10.3389/fimmu.2025.1602235
Justiz, A., Goyal, A., & Varacallo, M. (2025). Systemic lupus erythematosus. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK535405/
Kim, J., & Kim, H. (2019). Microbiome of the skin and gut in atopic dermatitis (AD): Understanding the pathophysiology and finding novel management strategies. Journal of Clinical Medicine, 8(4), 444. https://doi.org/10.3390/jcm8040444
Kume, M., Din, J., & Zegarra-Ruiz, D. F. (2025). Dysregulated intestinal host-microbe interactions in systemic lupus erythematosus: Insights from patients and mouse models. Microorganisms, 13(3), 556. https://doi.org/10.3390/microorganisms13030556
Lee, S. , Lee, E., Park, Y. & Hong, S. (2018). Microbiome in the gut-skin axis in atopic dermatitis. Allergy, Asthma & Immunology Research, 10(4), 354–362. https://doi.org/10.4168/aair.2018.10.4.354
Loscalzo, J., Fauci, A., Kasper, D., Hauser, S., Longo, D., & Jameson, J. (2022). Harrison. Principios de Medicina Interna (21.ª ed.). McGraw-Hill Education.
Mayo Clinic. (2025). ¿Qué son los probióticos y los prebióticos? https://www.mayoclinic.org/es/healthy-lifestyle/nutrition-and-healthy-eating/expert-answers/probiotics/faq-20058065
McAleer, M., & Irvine, A. (2013). The multifunctional role of filaggrin in allergic skin disease. The Journal of Allergy and Clinical Immunology, 131(2), 280–291. https://doi.org/10.1016/j.jaci.2012.12.668
Pan, Q., Guo, F., Huang, Y., Li, A., Chen, S., Chen, J., Liu, H. F., & Pan, Q. (2021). Gut microbiota dysbiosis in systemic lupus erythematosus: Novel insights into mechanisms and promising therapeutic strategies. Frontiers in Immunology, 12, 799788. https://doi.org/10.3389/fimmu.2021.799788
Parodi, E., Novi, M., Bottino, P., La Porta, E., Merlotti, G., Castello, L. M., Gotta, F., Rocchetti, A., & Quaglia, M. (2025). The complex role of gut microbiota in systemic lupus erythematosus and lupus nephritis: From pathogenetic factor to therapeutic target. Microorganisms, 13(2), 445. https://doi.org/10.3390/microorganisms13020445
Real Academia Española. (2025). Estrógeno. Diccionario de la lengua española (23.ª ed., versión 23.8 en línea). https://dle.rae.es
Sanitas. (2023). Hormonas femeninas: prolactina. https://www.sanitas.es/biblioteca-de-salud/embarazo-maternidad/lactancia/prolactina
Sánchez, J., Ospino, M., Salas, J., & Morales, J. (2023). Lupus eritematoso sistémico: Generalidades sobre su fisiopatología, clínica, abordaje diagnóstico y terapéutico. Revista Bioanálisis. https://revistabioanalisis.com/images/Rev%20144n/nota%205.pdf
Yao, K., Xie, Y., Wang, J., Lin, Y., Chen, X., & Zhou, T. (2023). Gut microbiota: A newly identified environmental factor in systemic lupus erythematosus. Frontiers in Immunology, 14, 1202850. https://doi.org/10.3389/fimmu.2023.1202850
Zhang, L., Qing, P., Yang, H., Wu, Y., Liu, Y., & Luo, Y. (2021). Gut microbiome and metabolites in systemic lupus erythematosus: Link, mechanisms and intervention. Frontiers in Immunology, 12, 686501. https://doi.org/10.3389/fimmu.2021.686501