Gestational hyperandrogenism
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Abstract
Hyperandrogenic conditions in pregnancy are rare, but arise more frequently due to an ovarian pathology of recent onset in pregnancy. Hyperandrogenemia in a pregnant woman can cause virilization in both the woman and her fetus, however the severity varies, depending on the time of onset of the increase in maternal androgen production and its severity. There are maternal and fetal causes, in which benign ovarian causes such as luteoma and theca lutein cysts are the most frequent. Other tumors causing hyperandrogenism in pregnancy include Sertoli-Leydig cell tumors and Krukenberg tumors. Androgen-secreting adenomas and carcinomas are rare causes of gestational hyperandrogenism. Unfortunately, the treatment during pregnancy is very limited, however both luteomas and theca lutein cysts usually remit in postpartum. Within the fetal causes, it include the deficiency of 3beta-hydroxysteroid dehydrogenase, 11beta-hydroxylase deficiency, and the placental aromatase deficiency, in which, the third one is the most frequent but at the same time very rare.
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